Hypothyroidism Primary Clinical Trial
Official title:
Hypothyroidism Treatment in Aging and Thyroid Cancer
This study was a prospective, single-center, open-label, non-randomized, pharmacokinetic study using stable isotope carbon-13 labeled levothyroxine
Setting The study was conducted on the clinical research unit of an academic medical center.
Participants Adults of any age being treated with levothyroxine for hypothyroidism were
studied.
Interventions A single dose of 13C- LT4 was administered to hypothyroid subjects taking
levothyroxine replacement.
Main Outcomes and Measures Eighteen serial plasma samples were collected. One sample was
obtained before the 13C- LT4 dose and the remainder over the 312-hour period post-dosing.
13C- LT4 concentration was quantified using validated liquid chromatography tandem mass
spectrometry methods. Pharmacokinetic analysis was conducted using linear log trapezoidal
non-compartmental analysis using Phoenix 6.4.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04988802 -
The Effect of Dietary Supplements for Pregnant Women on Levothyroxine Absorption
|
N/A | |
| Recruiting |
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Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
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Phase 3 |