Outcomes After Hypotensive Neuraxial Anesthesia in Total Hip Arthroplasty

Status Completed

Clinical Trial Summary

This is a retrospective chart review to determine if neuraxial anesthesia is associated with worse outcomes after Primary Total Hip Arthroplasty.

Clinical Trial Description

The goal of this study is to determine if hypotensive neuraxial anesthesia is associated with worse outcomes in Primary Total Hip Arthroplasty. The plan to analyze the outcomes is listed below: Primary outcomes: Multiple logistic regression will be used to compute the adjusted odds ratios of any postoperative complications (MI, CVA, death) , adjusting for covariates including duration of intraoperative mean arterial pressure of less than pre-defined threshold, such as 55, or 60 mmHg mean blood pressure. Sensitivity analyses will also consider the effects of intra-operative hypotension (IOH) defined as mean blood pressure of less than 40, 45, 50, 55, 60, and 65 mm Hg. Secondary outcomes: Multiple logistic regression will be to compute the adjusted odds ratios of individual postoperative complications, (such as MI, CVA, stroke) , adjusting for covariates including duration of intraoperative mean blood pressure of less than pre-defined threshold, such as 55, or 60 mmHg mean blood pressure. Sensitivity analyses will also be conducted to test the effects of extend of IOH on complications. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03973320
Study type	Observational
Source	Hospital for Special Surgery, New York
Contact
Status	Completed
Phase
Start date	December 27, 2018
Completion date	November 18, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04062994` - A Clinical Decision Support Trial to Reduce Intraoperative Hypotension
Active, not recruiting	`NCT02016599` - Effects of Transitional Circulation in ELBW Infants
Recruiting	`NCT05836610` - Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates	Phase 4
Suspended	`NCT02315937` - Hemodynamic Assessment During Spinal Anesthesia Using Transthoracic Echocardiography'	N/A
Completed	`NCT03215797` - Phenylephrine or Norepinephrine for a Better Hemodynamic Stability	Phase 3
Completed	`NCT02907931` - Carotid Doppler Ultrasound for the Measurement of Intravascular Volume Status	N/A
Recruiting	`NCT02532270` - Detecting Hypotension By Continuous Non-invasive Arterial Pressure Monitoring	N/A
Completed	`NCT02437799` - Dicrotic Notch and Hypotension at Caesarean Under Spinal Anaesthesia	N/A
Completed	`NCT02802683` - Hemodynamic Impact of Hyperbaric Versus Isobaric for Spinal Anesthesia During Cesarean Delivery	Phase 4
Completed	`NCT01930227` - Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hypotension After Spinal Anesthesia in Parturients	N/A
Not yet recruiting	`NCT01941472` - Transcutaneous pO2, Transcutaneous pCO2 and Central Venous pO2 Variations to Predict Fluid Responsiveness	N/A
Completed	`NCT02146898` - The Severity Of Hypotension Comparing Three Positions During Spinal Anesthesia For Cesarean Delivery	N/A
Recruiting	`NCT01434251` - Treatment of Hypotension of Prematurity (TOHOP)	N/A
Completed	`NCT01592669` - Passive Leg Raising Attenuates and Delays Tourniquet Deflation-induced Hypotension and Tachycardia	N/A
Withdrawn	`NCT01183741` - Accuracy of Non-Invasive Blood Pressure Measurement in Adults	Phase 3
Completed	`NCT00991627` - Different Approaches to Maternal Hypotension During Cesarean Section	Phase 4
Withdrawn	`NCT00750516` - Lactic Acid Levels In Hypotensive Patients Without(Standard) and With Tourniquet
Completed	`NCT00115726` - Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure	Phase 4
Recruiting	`NCT05513066` - Management Arterial Hypotension During Planned Caesarean Section, Intravenous Ephedrine/Phenylephrine Mixture Versus Intravenous Baby Noradrenaline
Completed	`NCT04089644` - Manual vs Closed-loop Control of Mean Arterial Pressure	N/A