Hypotension Clinical Trial
Official title:
A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability to Improve Perioperative Outcome During Spinal Anaesthesia for Caesarean Section
Hypotension occurs commonly during spinal anaesthesia for caesarean section with maternal and fetal adverse effects. The investigators developed a double-vasopressor automated system incorporating continuous non-invasive haemodynamic monitoring using NexfinTM with a two-step algorithm.
Hypotension occurs commonly during spinal anaesthesia for caesarean section with maternal and
fetal adverse effects. We developed a double-vasopressor automated system incorporating
continuous non-invasive haemodynamic monitoring using Nexfin cardiac output monitor with a
two-step algorithm. The system delivered phenylephrine 25 mcg or ephedrine 2 mg (if heart
rate<60 beats.min-1) every 30 seconds when systolic blood pressure was between 90-100% of
baseline. The system delivered phenylephrine 50 mcg or ephedrine 4 mg (if heart rate<60
beats.min-1) every 30 seconds when systolic blood pressure was <90% of baseline.
A randomised controlled trial will be done to compare with manual bolus technique. With the
manual bolus technique, phenylephrine 50mcg or ephedrine 4mg (if heart rate<60 beats.min-1)
every 60 seconds when systolic blood pressure was between 90-100% of baseline. The system
delivered phenylephrine 100mcg or ephedrine 8mg (if heart rate<60 beats.min-1) every 60
seconds when systolic blood pressure was <90% of baseline.
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