A Study for Patients With Neurogenic Orthostatic Hypotension

Status Completed

Clinical Trial Summary

We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright position) due to Parkinson's disease, multiple system atrophy, pure autonomic failure or autonomic neuropathies (i.e. neurogenic orthostatic hypotension). Symptoms of low blood pressure include dizziness, lightheadedness, changes in vision and generalized weakness upon standing. The main effect of the drug being studied is to increase blood pressure in the upright position so symptoms will decrease. The purpose of this clinical study is to further assess the clinical benefit of midodrine hydrochloride (ProAmatine®), an approved treatment for orthostatic hypotension. During the course of the study, participants will receive either ProAmatine® or a placebo. Assessments will be made using questionnaires that measure symptom and activity levels. Blood pressure in the lying down and standing positions will be measured at each visit.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00046475
Study type	Interventional
Source	Takeda
Contact
Status	Completed
Phase	Phase 4
Start date	December 1, 1997
Completion date	November 24, 1999

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02705755` - TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)	Phase 2
Completed	`NCT00555880` - Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension	Phase 4
Terminated	`NCT00046163` - A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension	Phase 4
Completed	`NCT02280369` - Posture Detection for Automated Abdominal Binder	N/A
Withdrawn	`NCT03248271` - Effects of Insulin on Hypotension and Sarcopenia
Completed	`NCT00117585` - Orthostatic Hypotension in Rehabilitation Patients	N/A
Completed	`NCT03900000` - Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease	N/A
Completed	`NCT03555799` - Evaluation of Changes of Venous Return After Spinal and Epidural Analgesia and Anesthesia by Ultrasound Guided Vena Cava Diameter Measurement
Terminated	`NCT02963181` - Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension	Early Phase 1
Completed	`NCT03602014` - Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury	Phase 4
Completed	`NCT02700399` - Study of Pulse Pressure During Tilttable and Erigo® in Adult Patients With Acquired Brain Injury	N/A
Recruiting	`NCT01866787` - Study on Baroreceptor Function in Relation to Orthostatic Blood Pressure Regulation After Hip Surgery	N/A
Enrolling by invitation	`NCT04369131` - Controlling Orthostatic Hypotension in People With Cervical Spinal Cord Injury	N/A