Hypotension Drug-Induced Clinical Trial
Official title:
Crystalloid Versus Crystalloid and Colloid Combination Preload for Prevention of Hypotension in Patients Undergoing Elective Caesarean Section Under Intrathecal Anesthesia
The aim of this study was to compare between crystalloid versus crystalloid and colloid
combination preloads for prevention of hypotension following intrathecal anaesthesia in
patients undergoing elective Caesarean section.
To examine weather baseline perfusion index could predict the incidence of
intrathecal-induced hypotension during Caesarean section.
Intrathecal anesthesia is the most commonly used technique for elective Caesarean section all
over the world.
One of the most common complications of this technique is hypotension. It's incidence is more
than 80% without any prophylactic measures, this hypotension has adverse effects on both
mother ( causing nausea and vomiting ) and foetus ( causing acidosis and neurological defects
).
This complication can be managed by several ways like fluid therapy, usage of vasopressors or
combination between both of them.
Among the type of fluids ( crystalloid or colloid ) it's still not known which one of them is
better. Crystalloid has a short intravascular half-life because of its rapid distribution
into the interstitial space. On the other hand colloid remains longer within the
intravascular space.
Change in baseline peripheral vascular tone due to pregnancy may affect the degree of such
hypotension. The perfusion index ( PI ) derived from a pulse oximeter has been used for
assessing peripheral perfusion dynamics due to changes in peripheral vascular tone.
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