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Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces

Hypospadias Clinical Trial

Official title:
Comparison of Structural and Molecular Genetic Properties Between Normal and Hypospadic Children's Prepuces

Clinical Trial Summary

The aim of this study is to compare prepuce tissue samples from healthy male children who applied for circumcision and children with isolated hypospadias. Estrogen receptor 1 (ER1), androgen receptor (AR), FGFR2, transforming growth factor beta (TGF beta) and HOXA13 gene expression in the prepuce is planned to investigate via polymerase chain reaction (PCR) method. Mucosal vascular and nerve densities, and extracellular matrix density of laminin and collagen protein is planned to investigate via immunohistochemical examination.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03838458
Study type Observational
Source Trakya University
Contact
Status Completed
Phase
Start date January 7, 2019
Completion date March 10, 2020
View Details
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