Hyposalivation Clinical Trial
Official title:
The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora in Subjects With Reduced Salivary Secretion Rate
The test group consisted of eighteen subjects with hyposalivation used probiotic tablets (≥ 4/day) and gel (once a week) (streptococci, bicarbonate and carbamide) for 3 months and 9 used placebo tablets and gel. The salivary secretion rates were measured and microbial samples collected and analysed using cultivation technique twice both at baseline and at the 3-month follow up (1-2 weeks between the appointments).
The aim was to analyse the effect of daily intake of probiotic alpha-haemolytic facultative
anaerobic streptococci (Streptococcus oralis), pH-rising components and Stevia on the oral
microflora in hyposalivated subjects.
Material and methods: Subjects with hyposalivation (unstimulated secretion rate of < 0.1
ml/min and/or a stimulated secretion rate < 0.7 ml/min) and ≥ 10 000 cfu/ml of mutans
streptococci and/or lactobacilli on the tongue or in the supragingival plaque were included.
Eighteen subjects used probiotic tablets (≥ 4/day) and gel (once a week) for 3 months and 9
used placebo tablets and gel. The salivary secretion rates were measured and microbial
samples collected and analysed using cultivation technique twice both at baseline and at the
3-month follow up (1-2 weeks between the appointments).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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