Hypoperfusion Clinical Trial
Official title:
Effects of Citrulline on Gut Functioning During Excercise
During exercise, splanchnic perfusion is compromised, resulting in organ damage in healthy individuals. Improving the availability of NO might result increase splanchnic perfusion and prevent organ damage during exercise.
The gastrointestinal (GI) tract plays an important role in the human body. The wall of the
GI system regulates digestion and absorption of nutrients and it also has a very important
function as a barrier between internal and external environment. The penetration of harmful
substances and microbiota of the GI lumen (external environment) to the systemic circulation
(internal environment) depends on this barrier. Previous studies have shown that exercise in
healthy subjects provides hypoperfusion of the splanchnic area, resulting in intestinal
damage, increased small intestinal permeability and liver damage. Similar splanchnic
hypoperfusion occurs in patients with compromised circulation.
During episodes of splanchnic hypoperfusion, the de novo synthesis of nitric oxide (nitric
oxide, NO) from arginine is compromised. This impaired NO synthesis may play a role in the
development of organ dysfunction during exercise. L-citrulline administration, a precursor
of arginine and NO, may result in improved NO availability and organ perfusion, thereby
preventing organ damage.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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