Role of GLP-1 in Hyperinsulinemic Hypoglycemia Post-bariatric Surgery

Status Recruiting

Clinical Trial Summary

The purpose of this study is to evaluate the role of GLP-1 in causing extreme postprandial glucose reductions after bariatric surgery in a subset of patients who have severe symptomatic hypoglycemia.

Clinical Trial Description

The physiologic mechanisms mediating the glucose-lowering effect of Roux-en-Y Gastric Bypass (RYGB) or post-Vertical Sleeve Gastrectomy (VSG) are unknown. The reduction in glucose excursions prior to weight loss has lead to postulates that the incretin hormone, GLP-1, may play an important role.

The purpose of this study is to evaluate the role of GLP-1 in causing extreme postprandial glucose reductions in a subset of post-bariatric patients through the pharmacologic blockade of the GLP-1 receptor in post-RYGB or post-VSG patients with severe symptomatic hypoglycemia. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Hypoglycemia

Clinical Trial Details

NCT number	NCT02550145
Study type	Interventional
Source	Stanford University
Contact	Colleen Craig, M.D.
Phone	650-736-2056
Email	cmcraig@stanford.edu
Status	Recruiting
Phase	Phase 1
Start date	February 2014

View Details

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