Hypoglycemia Clinical Trial
Official title:
Hypoglycemia and Endothelial Function
Hypothesis: Low blood sugar (hypoglycemia) decreases function of the lining of the blood
vessels in normal humans.
This study is designed to explore how hypoglycemia affects the function of the blood vessel
lining. This will be determined by measuring blood flow to the arm before and after
occlusion of flow. Blood vessel function will be measured before induction of hypoglycemia,
during insulin induced hypoglycemia, and after recovery from hypoglycemia. A second study
will be done but without hypoglycemia.
Purpose: The purpose of the research is to learn more about how low blood sugar (low blood
glucose or hypoglycemia) affects the way the blood vessels work in healthy people. Subjects
who participate in this research project must be in good health and taking no medications.
Methods: A screening visit to the Clinical Research Center of the Ohio State University will
be used to assess eligibility to participate. The main study consists of two visits to the
Clinical Research Center that occur two to four weeks apart. Each of these visits will
involve a procedure known as an insulin clamp. This involves giving insulin and sugar water
into a vein. The amount of sugar given varies to keep the blood sugar at a predetermined
level. For one of the two visits the blood sugar will be low and the other it will be
normal. The function of the blood vessels will be measured three times during each study by
measuring blood flow before and after stopping blood flow to the arm for 5 min.
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Observational Model: Case Control, Time Perspective: Prospective
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