Hypertriglyceridemia Clinical Trial
Official title:
Effects of Chia Seed Consumption in Comparison With Marine Omega-3 Supplementation on the Concentration of Blood Lipid and Inflammatory Factors in Hypertriglyceridemic Patients
Verified date | March 2024 |
Source | Shahid Beheshti University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Lifestyle changes including diet therapy and weight loss can improve hypertriglyceridemia (HTG) . Furthermore, increasing omega-3 fatty acids intake has therapeutic effects on HTG. Alpha-linolenic acid is the precursor of long-chain omega-3 fatty acid and it is abundant in sources such as chia seeds and flax seeds. Considering the high fiber and omega-3 content of chia seeds and the existing mechanisms for improving lipid profile through fiber and omega-3, animal studies have shown the positive role of chia seed consumption on lipid profile, glycemic and lipid factors, and inflammation. However, in human studies, conflicting results have been obtained and some studies have shown beneficial effects on blood lipid, glycemic, and inflammatory factors, but in some studies, no effect has been observed. The objective of this study is to determine the effects of chia seed consumption on lipids, glycemic and inflammatory factors in people with HTG.
Status | Completed |
Enrollment | 66 |
Est. completion date | March 16, 2024 |
Est. primary completion date | March 2, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - - Individuals who had fasting triglyceride concentration 150-499 mg/dL in their two previous tests Exclusion Criteria: - Being treated with fibrate medications - Being treated glucocorticoids - Being treated with anticoagulants (except aspirin) - Continuous use of omega-3 supplements or in the past month - End-stage kidney disease - Acquired immunodeficiency syndrome patients - Cancer patients undergoing chemotherapy or radiotherapy - Patients with liver cirrhosis - Pregnancy or lactation. |
Country | Name | City | State |
---|---|---|---|
Iran, Islamic Republic of | Clinical Nutrition Research Unit, National Nutrition and Food Technology Research Institute | Tehran |
Lead Sponsor | Collaborator |
---|---|
Shahid Beheshti University | National Nutrition and Food Technology Institute |
Iran, Islamic Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Plasma concentration of triglycerides | Fasting plasma concentration of C-reactive protein and IL-6 | 8 week | |
Secondary | Weight loss | Body wight loss (kg) | 8 week | |
Secondary | Plasma concentration of insulin | Fasting plasma concentration of insulin | 8 weeks | |
Secondary | Plasma inflammatory factors concentration | Fasting plasma concentration of C-reactive protein and IL-6 | 8 week |
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