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NCT00018720 Clinical Trial

Regulation of Sterol Homeostasis

Hypertriglyceridemia Clinical Trial

Official title:
Regulation of Sterol Homeostasis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00018720
Other study ID # GAST-026-95F
Secondary ID
Status Completed
Phase N/A
First received July 3, 2001
Last updated January 20, 2009
Start date April 1996
Est. completion date December 2000

Study information
Verified date December 2004
Source VA Office of Research and Development
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date December 2000
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 75 Years
Eligibility Hypertriglyceridemia and normal controls with normal lipids

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United States VA Medical Center Minneapolis Minnesota

Sponsors (1)
Lead Sponsor Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States, 

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