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Hypertriglyceridemia clinical trials

View clinical trials related to Hypertriglyceridemia.

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NCT ID: NCT03783377 Completed - Clinical trials for Hypertriglyceridemia

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)

Start date: March 8, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single- and multiple doses of ARO-APOC3 in healthy adult volunteers and in patients with severe hypertriglyceridemia and familial chylomicronemia syndrome (FCS).

NCT ID: NCT03747224 Completed - Dyslipidemias Clinical Trials

Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients

Start date: January 7, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetcs and pharmacodynamics of single- and multiple doses of ARO-ANG3 in healthy adult volunteers and in dyslipidemic patients including familial hypercholesterolemia and severe hypertriglyceridemia.

NCT ID: NCT03693131 Completed - Clinical trials for Hypertriglyceridemia

Efficacy of MND-2119 in Participants With Hypertriglyceridemia

Start date: October 27, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of MND-2119 compared to EPADEL CAPSULES 300 in participants with hypertriglyceridemia.

NCT ID: NCT03649269 Completed - Clinical trials for Hypertriglyceridemia

PC-300 Tea Effect on Triglyceride Levels

Start date: January 1, 2014
Phase: N/A
Study type: Interventional

Herbal medicine represents an alternative for treating dyslipidemia. The aim of this project was to evaluate the PC-300 tea (Eryngium heterophyllum egelm + Amphipterygium adstringens) against hypertriglyceridemia. Baseline samples of serum total cholesterol and triglycerides were obtained and measured again after 1 month of treatment with the following two alternatives: 1) PC-300, one cup half an hour before eating, and 2) bezafibrate 200 mg/d.

NCT ID: NCT03591588 Completed - Metabolic Syndrome Clinical Trials

Effects of Diet Interventions on Monocytes in Metabolic Syndrome

Start date: April 1, 2016
Phase: N/A
Study type: Interventional

Subjects with hypertriglyceridemia and metabolic syndrome are being recruited and receive diet interventions with either a high-saturated fat diet or a low-fat high protein diet for 4 days (days 1-4) and a breakfast on day 5. Blood samples are collected on day 1 and day 5 to examine lipid levels and circulating monocyte phenotypes.

NCT ID: NCT03508687 Completed - Clinical trials for Hypertriglyceridemia

Study of Gemcabene in Adults With FPLD

Start date: March 13, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The overall objective of this study is to assess the efficacy and safety of two dosing regimens of gemcabene (300 mg once daily for 24 weeks or 300 mg daily for 12 weeks followed by 600 mg daily for 12 weeks) in up to eight patients with Familial Partial Lipodystrophy with high triglycerides and Non-Alcoholic Fatty Liver Disease. The study will consist of a six week Wash Out Period, up to a 28 day Screening Period, a 24 week Treatment Period, and a follow-on safety assessment four weeks post final dose. Study participation will last approximately 4 months and includes at least 9 study visits, and can be as many as 11 study visits.

NCT ID: NCT03452228 Completed - Clinical trials for Severe Hypertriglyceridemia (sHTG)

Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis

Start date: June 7, 2018
Phase: Phase 2
Study type: Interventional

The primary objective is to determine the change in Triglyceride (TG) levels following 12 weeks of repeated Intravenous (IV) doses of evinacumab.

NCT ID: NCT03415568 Completed - Hyperlipidemias Clinical Trials

Effects of MCDG Oil on Postprandial Lipid Metabolism

Start date: June 30, 2017
Phase: N/A
Study type: Interventional

It is well known that medium chain triglycerides (MCTs) and diacylglycerols (DGs) have effects on lowering circulating triglycerides (TGs). In this study, the mixture of MCTs and DGs (MCDGs) examined whether it has beneficial effects on postprandial lipids metabolism compared to long-chain triglycerides (TGs).

NCT ID: NCT03415152 Completed - Clinical trials for Hypertriglyceridemia

A Prospective Observational Program Using Digital Technology Tools to Enhance Patient Adherence to Omacor Therapy

DIAPAsOn
Start date: January 24, 2018
Phase:
Study type: Observational

A prospective observational program using digital technology tools to enhance patient adherence to Omacor therapy

NCT ID: NCT03398005 Completed - Clinical trials for Hypertriglyceridemia

A Phase 3 STudy of CaPRe In LOwering Very hiGh TriglYcerides (TRILOGY 1)

TRILOGY 1
Start date: January 23, 2018
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to determine the efficacy of CaPre 4 g daily, compared to placebo, in lowering fasting triglyceride (TG) levels in patients with fasting TG levels ≥500 mg/dL and ≤1500 mg/dL (≥5.7 mmol/L and ≤17.0 mmol/L) after 12 weeks of treatment. Approximately 615 subjects will be screened to obtain 245 randomized subjects following a 2.5:1 treatment allocation ratio (CaPre: placebo).