Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol

Hyperthyroidism Clinical Trial

Official title:

Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03393728
• Other study ID #: YaoundeCH
• Status: Completed
• Phase: Phase 4
• First received: December 21, 2017
• Last updated: January 5, 2018
• Start date: September 1, 2008
• Est. completion date: September 30, 2009

Study information

• Verified date: January 2018
• Source: Yaounde Central Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

Description:

Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest.

The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: September 30, 2009
• Est. primary completion date: December 30, 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism

• naïve of all treatment specific for hyperthyroidism.

• aged 18-70 years

Exclusion Criteria:

• Patients already under a specific treatment for hyperthyroidism

• Patients taking beta blockers or any other cardiospecific treatment

• Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure

• Contraindications to the prescription of beta blockers

Related Conditions & MeSH terms

• Hyperthyroidism

Intervention

Drug:
• Propanolol
72-hour propanolol before specific treatment of hyperthyroidism

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Yaounde Central Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Heart rate variability	Sympatho vagal tone measures	72 hours
Secondary	Heart rate	Heart rate	72 hours