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Hyperplasia clinical trials

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NCT ID: NCT04385667 Completed - Clinical trials for Atypical Endometrial Hyperplasia

LVN- IUS Versus Oral Megesterol Acetate in Treatment of Atypical Endometrial Hyperplasia

Start date: May 20, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

This randomized controlled trial is aimed to compare the efficacy between Megestrol acetate (MA) and the levonorgestrel intrauterine system (LNG-IUD) regarding the ability and duration to produce complete regression for cases with atypical endometrial hyperplasia.

NCT ID: NCT04383093 Completed - Metabolic Syndrome Clinical Trials

Tadalafil Plus Tamsulosin for Male LUTS and ED

Start date: January 1, 2017
Phase:
Study type: Observational

Metabolic Syndrome (MetS) is a complex epidemic disorder with an impact on both lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Combination therapy of daily tadalafil and tamsulosin may provide relief to both diseases. Aim of the present study is to assess the impact of combination therapy of Tadalafil 5mg plus Tamsulosin 0.4mg on LUTS and ED, according to presence vs. absence of Mets.

NCT ID: NCT04378387 Completed - Clinical trials for Primary Aldosteronism

Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism

Start date: January 1, 2005
Phase:
Study type: Observational

Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two adrenal veins is still considerable, and there is no general consensus on the criteria that should be used for the interpretation of the results of an AVS study in these specific cases.

NCT ID: NCT04331301 Completed - Clinical trials for Prostatic Hyperplasia

Bipolar Needlescopic Enucleation Versus Vapoenucleation of BPH

Start date: January 10, 2017
Phase: N/A
Study type: Interventional

Transurethral resection of the prostate (TURP) is the current standard procedure for men with prostate volume 30-80 gm. In case with large prostate adenoma (>80 g), the resection time required by TURP is associated with increased risk of TUR syndrome, blood loss and other complications. Many types of minimally invasive surgery exist along with new equipment and techniques. Many types of laser devices such as greenlight laser, thulium laser and holmium laser, are used to enucleate the prostate. Increasing evidence has proven their safety and efficacy However, the use of laser devices is difficult and associated with steep learning curve and high medical expenses. PKEP is a safe and effective procedure for the treatment of bladder obstruction secondary to BPH. This procedure not only improves maximum flow rate at 3 and 12 months after surgery, but it also improves all other recorded parameters (IPSS, QOL, IEFF-5, PVR, PSA). A button electrode can be effectively used to enucleate the prostate because of its powerful vaporisation and strong coagulation (B-TUEP technique) ,such as that with a holmium laser, thulium laser and greenlight laser. However its associated with short term complication as early irritative symptoms, Bulai reported that 16.7% of the patients suffering from early irritative symptoms while Geavlete reported that 11.4% of patient suffering from early irritative symptoms.

NCT ID: NCT04308070 Completed - Clinical trials for Benign Prostatic Hyperplasia

Acute Hemostasis Following the Use of the AQUABEAM® System for the Treatment of Benign Prostatic Hyperplasia III

AHAIII
Start date: July 18, 2017
Phase: N/A
Study type: Interventional

A dual-arm prospective, interventional clinical trial to evaluate the safety and performance of obtaining hemostasis with catheters along with the use or absence of a hemostatic agent following treatment with the AQUABEAM System.

NCT ID: NCT04299425 Completed - Clinical trials for Primary Hyperparathyroidism

Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy

NIRAF
Start date: March 13, 2020
Phase: N/A
Study type: Interventional

This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures. It compares risk-benefits and outcomes in PTx patients where NIRAF detection with PTeye for parathyroid identification is either used or not used.

NCT ID: NCT04275076 Completed - Clinical trials for Prostate Hyperplasia

HoLEP Vs BPEP for Large Prostatic Adenoma

enucleation
Start date: February 1, 2018
Phase: Phase 3
Study type: Interventional

Benign prostatic hyperplasia (BPH) is one of the most common urinary disorders in elderly males. The symptoms of BPH include impaired physiological and functional well-being, which interferes with daily living. At present, transurethral resection of the prostate (TURP) is the standard surgical treatment. However, the high rate of complications associated with TURP is a major drawback of this procedure. Holmium laser enucleation of the prostate (HoLEP) was proven to be an effective surgical treatment for BPH with no prostate size limitation with adequate hemostasis, bipolar enucleation of the prostate (BPEP) has been introduced as an alternative energy source with a promising outcome with equal safety and efficacy

NCT ID: NCT04272216 Completed - Clinical trials for Benign Prostatic Hyperplasia

An Observational Study of Radial Access Embolization Procedures Using HydroPearl Microspheres

RAVI Registry
Start date: February 6, 2020
Phase:
Study type: Observational [Patient Registry]

This registry study is designed to collect data on the procedural success and complication rates in real-world patients undergoing HydroPearl embolization procedures via radial access.

NCT ID: NCT04271020 Completed - Clinical trials for Benign Prostatic Hyperplasia

Urodynamic Feasibility Study Utilizing the UroLift® System

UDS
Start date: October 25, 2018
Phase: N/A
Study type: Interventional

UDS evaluates the impact of Prostatic Urethral Lift (PUL) as measured by pressure flow, urodynamic testing (UDS) and an optional UroCuff Testing, an alternative urodynamic test. In addition, standard BPH measures such as symptoms, qualify of life, uroflowmetry, and post void residual will be evaluated at screening and at the follow-up visits.

NCT ID: NCT04263987 Completed - Clinical trials for Benign Prostatic Hyperplasia

A Comparison of Traditional and MOSES Laser Enucleation of the Prostate (MOLEP): A Prospective, Randomized, Double-blinded Control Trial A Comparison of Traditional and MOSES Laser Enucleation of the Prostate (MOLEP): A Prospective, Randomized, Double-blinded Control Trial

Start date: January 1, 2020
Phase: Phase 3
Study type: Interventional

Holmium laser enucleation of the prostate (HOLEP) has proven to be efficacious and safe for the treatment of benign prostatic hypertrophy (BPH). New laser technologies such as the Moses Pulse laser system provide for improved energy delivery which may decrease blood loss and operative time. We seek to evaluate Moses technology for enucleation of the prostate in the setting of BPH.