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Hyperphosphatemia clinical trials

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NCT ID: NCT05897502 Completed - Hyperphosphatemia Clinical Trials

Explore the Effectors of The Transtheoretical Model on Nutritional Education in Patients on Hemodialysis

Start date: July 4, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the improvement degree of nutritional care program on the nutritional status and eating habits of hemodialysis patients

NCT ID: NCT05764590 Completed - Clinical trials for Chronic Kidney Diseases

A Study to Evaluate Safety and Efficacy of AP-306 in Hyperphosphatemia Patients

Start date: February 20, 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to learn about the following questions in the patients receiving maintenance hemodialysis with elevated blood phosphorus: - How much effect AP-306 has assessed by blood phosphorus lowering; - How safe and tolerable AP-306 is. Participants will receive either following treatments: - AP-306, and - Sevelamer carbonate.

NCT ID: NCT05699239 Completed - Clinical trials for Hyperphosphatemia Patients on Hemodialysis

A Phase 2 Dose-finding Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis

Start date: February 8, 2023
Phase: Phase 2
Study type: Interventional

A phase 2, randomized, placebo-controlled, double-blind, dose-finding study of TS-172 in hyperphosphatemia patients on hemodialysis

NCT ID: NCT05577507 Completed - Clinical trials for Chronic Kidney Diseases

Efficacy and Safety of Cholestyramine in the Management of Hyperphosphatemia in Adult Hemodialysis Patients

Start date: March 30, 2023
Phase: Phase 4
Study type: Interventional

The aim of the study is to evaluate the efficacy and safety of cholestyramine in the management of hyperphosphatemia in hemodialysis patients. Colestilan is a non-metallic phosphate binder that acts as an anion-exchange resin. Colestilan itself is not absorbed after oral administration, and it is able to bind dietary phosphate within the gastrointestinal tract and thus prevent absorption of the mineral. Initial, Phase II, studies showed that it reduces serum phosphorus levels in dialysis patients with hyperphosphatemia without affecting serum calcium levels. There are no studies conducted about the feasibility and efficacy of cholestyramine as an oral phosphate binder in hemodialysis patients. Relying on the efficacy and safety of bile acid sequestrants such as colestilan and colestipol in the management of hyperphosphatemia and hypercholesterolemia in hemodialysis patients, cholestyramine is selected to be studied in hemodialysis patients. A total of 80 patients will be recruited and divided into 2 groups: - Group 1: (cholestyramine 12 gram), 40 patients will take a dose of cholestyramine 4-gram sachet in 150-200 ml water or juice three times daily within meals as an add on therapy with standard therapy calcium-based phosphate binder (Calcimate). Group 2: Control group, 40 patients will take only the standard therapy calcium-based phosphate binder (Calcimate). Time of the trial will be two months (8 weeks trial period) Baseline characteristics: The following data will be collected from all patients at baseline 1. Age, sex, weight, duration of ESRD and hemodialysis comorbidities. 2. Dialysis duration, serum phosphate level, serum calcium level, iPTH, BUN, Cr (mg/d L), Albumin (mg/d L), Hb (g m%), renal function test, liver function test, blood glucose level, TG, total cholesterol level, LDL-C, HDL.C. After the end of trial, we will examine if cholestyramine has a significant efficacy on reducing serum phosphate level in adult hemodialysis patients.

NCT ID: NCT04922645 Completed - Renal Insufficiency Clinical Trials

Auryxia (Ferric Citrate) Therapy for In-Center and Home Dialysis Participants

IMPACT
Start date: June 29, 2021
Phase: Phase 4
Study type: Interventional

This study is being conducted to demonstrate the effect of Auryxia, when used as the primary phosphate lowering therapy, on the overall cumulative use of erythropoiesis-stimulating agent and intravenous iron as well as on the laboratory parameters indicative of phosphate and anemia management.

NCT ID: NCT04789876 Completed - Hyperphosphatemia Clinical Trials

Effectiveness of The Phosphate Mobile App on Serum Phosphorus in Adult Hemodialysis Patients With Hyperphosphatemia

Start date: November 1, 2019
Phase: N/A
Study type: Interventional

This multi-centred randomized, open label-controlled trial consists of hemodialysis (HD) patients identified with hyperphosphatemia (>1.78mmol/L). The intervention group received a phosphate mobile app and the control group received one-off dietary counselling for 12 weeks. Serum phosphate was measured pre-and post-intervention.

NCT ID: NCT04771780 Completed - Hyperphosphatemia Clinical Trials

Phosphate Binder Switch Study of KHK7791 in Hyperphosphatemia Patients on Hemodialysis

Start date: March 15, 2021
Phase: Phase 3
Study type: Interventional

To investigate the safety of repeated administration of KHK7791 for 52 weeks while switching from a phosphate-binding agent to KHK7791 in Hemodialysis patients with hyperphosphatemia.

NCT ID: NCT04767581 Completed - Hyperphosphatemia Clinical Trials

Clinical Study of KHK7791 in Hyperphosphatemia Patients on Hemodialysis

Start date: March 8, 2021
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy of KHK7791 by comparing changes in serum phosphorus levels from baseline values between hemodialysis patients with hyperphosphatemia receiving repeated administration of KHK7791 for 8 weeks and those receiving placebo.

NCT ID: NCT04766398 Completed - Hyperphosphatemia Clinical Trials

Phosphate Binder-combination Study of KHK7791 in Hyperphosphatemia Patients on Hemodialysis

Start date: March 15, 2021
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy of KHK7791 in combination with phosphate binders by comparing changes in serum phosphorus levels between hemodialysis patients with hyperphosphatemia receiving repeated administration of KHK7791 30 mg in combination with phosphate binders for 6 weeks and those receiving placebo in combination with phosphate binders.

NCT ID: NCT04766385 Completed - Hyperphosphatemia Clinical Trials

Clinical Study of KHK7791 in Hyperphosphatemia Patients on Peritoneal Dialysis

Start date: March 3, 2021
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy of KHK7791 by comparing changes in serum phosphorus levels from baseline values between peritoneal dialysis patients with hyperphosphatemia receiving repeated administration of KHK7791 for 8 weeks and those receiving placebo.