Gene Expression in Hyperparathyroidism

Status Terminated

Clinical Trial Summary

Objectives:

1. To better define the differences in molecular genetics of parathyroid tumors in patients with MEN1, single gland parathyroid disease in patients less than 50 years old and single gland disease in patients greater than 50 years old.

2. To better define the incidence of HRPT2 mutation in young patients with primary hyperparathyroidism and determine whether routine testing in these patients is indicated.

Clinical Trial Description

Patient charts will be reviewed to collect demographic data, pre-operative and post-operative clinical and laboratory data, operative reports, and pathology reports. Archived formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients will be stained for parafibromin to evaluate for HRPT2 mutations. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03044600
Study type	Observational
Source	M.D. Anderson Cancer Center
Contact
Status	Terminated
Phase
Start date	November 7, 2012
Completion date	October 18, 2017

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