Hyperparathyroidism Clinical Trial
Official title:
Corticosteroid Rhythms in Hypoparathyroid Patients
The investigators hypothesise that parathyroid hormon (PTH) depletion interferes with normal activity of the hypothalamus-pituitary-adrenal (HPA)-axis and the renin-angiotensin-aldosterone-system (RAAS), which in turn may impact morbidity and quality of life. The main objective of the current study is to test if PTH deficiency influences the secretion of corticosteroids and whether any abnormalities in the HPA-axis and the RAAS-system can be reversed by PTH infusion.
Visit 1: Optimizing conventional treatment regarding s-magnesium, s-calcium, s-phosphorous
and 25-hydroxyvitamin D (25(OH)D)-levels.
Visit 2 (In-hospital 4-7 days): Day one: 24h microdialysis sampling, venous blood sampling
and 24h urine will be collected. Day 2: Start of PTH pump-treatment. Day 3-x: dose adjustment
of PTH pump therapy according to Calcium Levels, the first two days after started PTH six
daily venous blood-samplings will be performed. Day x: 24h microdialysis sampling and 24h
urine-sampling and a venous blood sampling. Restart of conventional treatment.
The Control patients (healthy volunteers and patients with hyperparathyroidism) will perform
24h microdialysis-sampling only.
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