Hyperparathyroidism Clinical Trial
Official title:
The Renin-Angiotensin-Aldosterone System and Parathyroid Hormone Control: The RAAS-PARC Study
This study will evaluate whether commonly used blood pressure medications called "ACE inhibitors" can lower parathyroid hormone.
The RAAS-PARC study will evaluate whether angiotensin-converting enzyme inhibitors (ACEi) can
lower parathyroid hormone (PTH) in normal controls and in individuals have a diagnosis of
primary hyperparathyroidism.
Emerging data has implicated the renin-angiotensin-aldosterone system (RAAS) activity with
increased PTH. The principal investigator, and other investigators, have previously shown
that inhibiting the RAAS may lower PTH. The current study will focus on:
1. Normal Physiology: Does an ACEi (which lowers angiotensin II and aldosterone) reduce PTH
in normal individuals?
2. Pathophysiology: Does an ACEi reduce PTH in individuals with primary
hyperparathyroidism?
The results of this study may have important implications for cardiovascular and skeletal
health, as both the RAAS and PTH have been implicated as mediators of these conditions.
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