Hyperparathyroidism Clinical Trial
Official title:
Study of the Efficacy and Safety on the Ultrasonic Ablation Treatment for Secondary Hyperthyroidism in Chronic Kidney Disease Patients.
It is difficulty for the treatment of secondary hyperparathyroidism in the chronic kidney disease (CKD) patients who had not succeeded medical therapy and could not get parathyroidectomy. The investigators suppose that ultrasonic ablation may be a valuable alternative treatment that help control secondary hyperparathyroidism in CKD patients presenting with enlarged parathyroid gland(s) visible at ultrasonography.
Secondary hyperparathyroidism (sHPT) is common in patients with chronic kidney disease
(CKD), including those who are undergoing long-term dialysis treatments. sHPT is damaged for
bone system, blood system, cardiovascular system, and so on. The treatment of the sHPT of
CKD's patient includes dietary phosphate restriction, the use of medicines, and
parathyroidectomy. In the mainland of China, there are not certain useful medicines to treat
sHPT, including the derivatives of vitamin D, calcimimetic agent, non calcium aluminum
phosphate binders. Furthermore, medical therapy is not always successful in achieving
adequate control of sHPT. Oral medications have efficacy limitations as well as
side-effects. Otherwise, surgery treatment can only be used for the patients with enlarged
parathyroid gland(s). The patients may suffer from the injury of operation,
hypoparathyroidism, or recurrence of hyperparathyroidism after parathyroidectomy.
Then ultrasonic ablation may become a valuable alternative treatment that help control sHPT
in selected patients presenting with enlarged parathyroid gland(s) visible at
ultrasonography,.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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