Hypernatraemia Clinical Trial
Official title:
Do Plasma Osmolality Changes Influence Ventilation, and Are There Gender Differences?
Primary hypothesis: osmolality changes influence the sensitivity of the respiratory center
to carbon dioxide, hyponatraemia causing hyperventilation, and hypernatraemia depressing
ventilation.
Secondary hypothesis: There are gender differences in the sensitivity to osmolality changes.
10 women and 10 men will on different occasions drink water or receive hypertonic saline
intravenously, in order to lower or increase plasma osmolality. The women will participate
during both faces of the menstruation cycle. On each occasion the subject´s sensitivity to
carbon dioxide will be tested, and blood samples will be drawn for analysis of blood
gases,electrolyte and osmolality.Subjects who interrupt participation before completion of
all planned occasions, will be substituted, so that 10 subjects of either sex will have
participated as planned. All results from all participants will be analyzed.
Healthy volunteers will on different occasions be subject to reduced plasma osmolality caused by drinking water, and increased osmolality caused by intravenous infusion of hypertonic saline.Before and after each osmolality change, sensitivity to carbon dioxide will be tested by partial rebreathing through a so called Bain-system. Throughout the whole experiment heart rate, blood pressure and oxygen saturation will be recorded.Blood samples will be collected before each rebreathing test and every 20 minutes during the two hours of water or salt load. Urine will be collected and analysed. ;
Allocation: Non-Randomized, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01974739 -
Hydrochloorthiazide and Hypernatriaemie
|
N/A |