Hyperlipoproteinemia Clinical Trial
Official title:
Systematic Study of Post Herapin Lipoprotein Lipase Activity and Lipoprotein Remodelling in Multifactorial Chylomicronemia
Purpose: The mechanism of most of the multifactorial chylomicronemia (MCM) remains elusive. In order to decipher the mechanisms involved in the occurrence of this disease, plasma TG lipolysis characteristics will be monitored for 60 minutes after heparin injection instead of the 10 minutes gold standard, in a large group of genotyped MCM patients.
Purpose: The mechanism of most of the multifactorial chylomicronemia (MCM) remains elusive.
In order to decipher the mechanisms involved in the occurrence of this disease, plasma TG
lipolysis characteristics will be monitored for 60 minutes after heparin injection instead
of the 10 minutes gold standard, in a large group of genotyped MCM patients.
Method: LPL, APOC2, APOA5, GPIHB1and APOE genotypes will be determined for each patient.
Basal lipid profiles including Apo B, CII, CIII, and lipoprotein lipase (LPL) concentration
will be measured in 62 MCM patients, in addition to LPL activity (PHLA) T0, T10 T30 T60
minutes, Assessment of TG chylomicron decrease Study of lipoprotein remodelling by agarose
gel electrophoresis.
Hypothesis To confirm the preliminary finding of high LPL activity in multifactorial
chylomicronemia To explore the interest of a longer assessment of LPL activity following
heparin injection. To establish if specific phenotypes could be identified among MCM patient
supporting the hypothesis of different mechanisms involved (ie overproduction or defect in
hepatic clearance)
;
Observational Model: Cohort, Time Perspective: Prospective
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