Elevated Serum HDL in Four Generations of a Nashville Family

Hyperlipidemias Clinical Trial

Official title:

Elevated Serum HDL in Four Generations of a Nashville Family

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00525109
• Other study ID #: 010535
• Status: Terminated
• Phase: N/A
• First received: September 4, 2007
• Last updated: March 16, 2017
• Start date: June 2004
• Est. completion date: June 2006

Study information

• Verified date: March 2017
• Source: Vanderbilt University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to determine the genetic basis of one family's hereditary hyper-HDL-emia using multiple modalities such as linkage analysis and gene array.

Description:

HDL, or good cholesterol, has been shown to protect against heart attack and stroke. How HDL works as a protective agent is not well understood. There is a family that has 4 generations of living members with high HDL level. In the study, after consent is obtained, we will obtain 2 tablespoons of blood from all the family members in order to study their cholesterol levels and to obtain DNA in order to determine if there is a pattern of inheritance for this trait. We will also have them fill out a questionnaire about their medical history, diet and activity level as all of these can affect their HDL levels. In addition we will obtain additional blood (about 2 tablespoons) for plasma, white blood cells and also perform a biopsy to obtain skin cells from a matched pair of family members with and without the trait in order to determine which genes might be turned on and off because of this trait. We also wish to study other families who have members with high HDL cholesterol as well. These individuals will be identified from a core database.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 3
• Est. completion date: June 2006
• Est. primary completion date: June 2006
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years and older

Eligibility

Inclusion Criteria:

• 26 living members of a family with HDL levels greater than 90mg/dl and several of whom will act as related age matched controls.

• The investigators will also identify individuals in a lipid core database with HDL's of greater than 90mg/dl who have normal or low LDL and triglyceride levels and determine if they have normal or low LDL and triglyceride levels and determine if they have family members (parents or siblings) who also have high HDL cholesterol.

Exclusion Criteria:

• Individuals who are not a member of the study family and individuals with high HDL's and elevated LDL and/or triglycerides.

Related Conditions & MeSH terms

• Hyperlipidemias

Intervention

Other:
• No Intervention
No intervention

Locations

Country	Name	City	State
United States	Vanderbilt University Medical Center	Nashville	Tennessee

Sponsors (1)

Lead Sponsor	Collaborator
Vanderbilt University Medical Center

Country where clinical trial is conducted

United States,