Hyperlipidemia Clinical Trial
Official title:
The Effects of Bilberry Fruit and Black Rice Derived Anthocyanins on Lipid Status in Adults
The primary aim of this study is to directly compare the two major types of anthocyanins found in the diet (cyanidin-type and delphinidin-type) on lipid status in adults.
Human intervention trials with anthocyanin-rich berry fruits/extracts such as whole
strawberries, elderberry juice and whortleberry extracts, and purified anthocyanins from a
mixture of blackcurrant and bilberry have been shown to beneficially alter biological markers
for CVD risk, with beneficial effects on lipid profiles common across these studies.
In a randomized 3 phase crossover study we aim to recruit 50 participants (men and women)
aged 45 years or more with a higher than optimal blood cholesterol level to consume capsules
containing (i) 320 mg anthocyanins derived from bilberry fruit (delphinidin type), (ii) 320
mg anthocyanins derived from black rice (cyanidin type) and (iii) a placebo control. Each
treatment will be ingested for 28 days with a wash-out period of 4 weeks in-between. Blood
samples will be collected at the start and end of each 28-day treatment period to assess
lipid status. In a subset of participants we will also investigate the relationship between
bilberry and black rice anthocyanin ingestion on RNA expression profiles that are known to be
involved in atherosclerosis, non-alcoholic fatty liver disease and reverse cholesterol
transport as well as faecal excretion of bile acids and lipids.
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