A Study to Evaluate the Lipid Regulating Effects of TRIA-662

Status Completed

Clinical Trial Summary

The purpose of this study is to determine the effectiveness and safety of TRIA-662 (also known as 1-MNA) in treating elevated triglyceride levels in patients not receiving lipid lowering treatment. This study will determine the effects of TRIA-662 on commonly measured blood fats that are known to be important in the prevention of vascular disease.

Clinical Trial Description

This is a randomized, double-blind, placebo-controlled, dose-ranging, multi-center study. Following a 6-8 week placebo and dietary-controlled baseline period, approximately 195 men and women with either hypertriglyceridemia or mixed hyperlipidemia with serum triglycerides (TG) > 200 mg/dl (2.26 mmol/l) will be randomized to receive either placebo, 30 mg TRIA-662 or 90 mg TRIA-662 three times daily for twelve weeks. Lipid and ancillary exploratory parameters will be evaluated at screening, during the baseline period, upon randomisation and throughout the 12-week active treatment period. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00758303
Study type	Interventional
Source	Cortria Corporation
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	September 2007
Completion date	December 2008

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00001154` - Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
Completed	`NCT02927184` - Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease	Phase 2
Completed	`NCT04640012` - Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics of DC371739 Single-Dose Treatment in Healthy Subjects	Phase 1
Completed	`NCT03213288` - Bilberry Fruit and Black Rice Derived Anthocyanins on Lipid Status	N/A
Completed	`NCT00382564` - Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease	N/A
Recruiting	`NCT02979704` - A Comparative Study of Rosuvastatin and Atorvastatin in Patients With Hyperlipidemia	Phase 2/Phase 3
Completed	`NCT02569814` - A Study to Compare the Pharmacokinetics and Safety of a Fixed Dose Combination of Fimasartan/Amlodipine/Rosuvastatin	Phase 1
Completed	`NCT02428998` - Safety for 24 Weeks Intake of Korean Red Ginseng in Adults	N/A
Completed	`NCT02280590` - Comparison of the Efficacy and Safety of Cresnon® and Crestor® in Patients With Hyperlipidemia	Phase 4
Completed	`NCT01678183` - Financial Incentives for Medication Adherence	N/A
Completed	`NCT01426412` - A Study of LY3015014 in Healthy Participants With Elevated Low Density Lipoprotein Cholesterol	Phase 1
Completed	`NCT01694446` - Regulation of Intestinal and Hepatic Lipoprotein Production by Glucose and Fructose	N/A
Completed	`NCT01131832` - Genetic Basis for Heterogeneity in Response of Plasma Lipids to Plant Sterols	Phase 4
Completed	`NCT00534105` - Lipid Metabolism in Gestational Diabetes	N/A
Recruiting	`NCT00408824` - Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)	N/A
Completed	`NCT00362206` - Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin	Phase 3
Terminated	`NCT00299169` - Randomized Trial Comparing N of 1 Trials to Standard Practice to Improve Adherence to Statins in Patients With Diabetes	Phase 4
Completed	`NCT00381992` - Risk Assessment of Long-Haul Truck Drivers	N/A
Completed	`NCT00414986` - Using Learning Teams for Reflective Adaptation for Diabetes and Depression	N/A
Completed	`NCT00701454` - Survey of Thai-Muslim Health Status	N/A