Clinical Trials Logo
  1. Home
  2. Hyperlipidemia
  3. NCT00457262
  4. Details
NCT00457262 Clinical Trial

Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women

Hyperlipidemia Clinical Trial

Official title:
Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00457262
Other study ID # 1344
Secondary ID
Status Completed
Phase N/A
First received April 4, 2007
Last updated April 4, 2007
Start date January 2006
Est. completion date August 2006

Study information
Verified date March 2007
Source Iran University of Medical Sciences
Contact n/a
Is FDA regulated No
Health authority Iran: Ethics Committee
Study type Interventional

Clinical Trial Summary

paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity

Description:

In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.

Recruitment information / eligibility
Status Completed
Enrollment 42
Est. completion date August 2006
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 51 Years to 57 Years
Eligibility Inclusion Criteria:

- Cessation of menes for more than 1 year, elevation for more than 1 year

- Elevation of FSH level

- Total cholesterol

- Triglyceride more than 200 mg/dl

Exclusion Criteria:

- Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease)

- Antihypertensive drugs

- Antibiotics

- Lipid lowering drugs

- Sex hormone treatment

- Hysterectomy

- Diet rich in soy protein

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

Intervention

Procedure:
• soy consumption

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Iran University of Medical Sciences

Outcome
Type Measure Description Time frame Safety issue
Primary decrease of LDL,increase of HDL,increase of paraoxonase 1
See also
  Status Clinical Trial Phase
Completed NCT00001154 - Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
Completed NCT02927184 - Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease Phase 2
Completed NCT04640012 - Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics of DC371739 Single-Dose Treatment in Healthy Subjects Phase 1
Completed NCT03213288 - Bilberry Fruit and Black Rice Derived Anthocyanins on Lipid Status N/A
Completed NCT00382564 - Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease N/A
Recruiting NCT02979704 - A Comparative Study of Rosuvastatin and Atorvastatin in Patients With Hyperlipidemia Phase 2/Phase 3
Completed NCT02569814 - A Study to Compare the Pharmacokinetics and Safety of a Fixed Dose Combination of Fimasartan/Amlodipine/Rosuvastatin Phase 1
Completed NCT02280590 - Comparison of the Efficacy and Safety of Cresnon® and Crestor® in Patients With Hyperlipidemia Phase 4
Completed NCT02428998 - Safety for 24 Weeks Intake of Korean Red Ginseng in Adults N/A
Completed NCT01678183 - Financial Incentives for Medication Adherence N/A
Completed NCT01694446 - Regulation of Intestinal and Hepatic Lipoprotein Production by Glucose and Fructose N/A
Completed NCT01426412 - A Study of LY3015014 in Healthy Participants With Elevated Low Density Lipoprotein Cholesterol Phase 1
Completed NCT01131832 - Genetic Basis for Heterogeneity in Response of Plasma Lipids to Plant Sterols Phase 4
Completed NCT00534105 - Lipid Metabolism in Gestational Diabetes N/A
Completed NCT00758303 - A Study to Evaluate the Lipid Regulating Effects of TRIA-662 Phase 2/Phase 3
Recruiting NCT00408824 - Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study) N/A
Completed NCT00362206 - Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin Phase 3
Terminated NCT00299169 - Randomized Trial Comparing N of 1 Trials to Standard Practice to Improve Adherence to Statins in Patients With Diabetes Phase 4
Completed NCT00701454 - Survey of Thai-Muslim Health Status N/A
Completed NCT00414986 - Using Learning Teams for Reflective Adaptation for Diabetes and Depression N/A