Variation in Anisotropy of the Spinal Cord in Patients With Hyperkyphosis

Status Completed

Clinical Trial Summary

Clinical Trial Description

Spinal cord compression is commonly seen in patients with severe kyphosis. However, conventional morphologic magnetic resonance imaging (MRI) was unable to detect the damage in microstructural integrity of the spinal cord around the apical vertebrae in these patients. The aim of the study was to evaluate the neuronal metrics/microstructure of the spinal cord around apical region in patients with hyperkyphosis using diffusion tensor imaging (DTI). Twenty-four patients with hyperkyphosis aged 46.1±22.8 years who underwent 3.0T MRI examination with DTI sequence were prospectively enrolled from July 2022 to January 2023. Patients were divided into three groups according to spinal cord/cerebrospinal fluid architecture (CSF) on sagittal-T2 MRI of the thoracic apex: Type A-circular cord with visible CSF, Type B-circular cord but no visible CSF at apical dorsal, and Type C-spinal cord deformed without intervening CSF. The Fractional Anisotropy (FA) values acquired from DTI were compared among different groups. Correlations between DTI parameters and global kyphosis (GK)/sagittal deformity angular ratio (SDAR) were evaluated using Pearson correlation coefficients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05987150
Study type	Observational
Source	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact
Status	Completed
Phase
Start date	July 1, 2022
Completion date	April 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03885466` - Nordic Walking for Individuals With Osteoporosis, Vertebral Fracture or Hyperkyphosis	N/A
Recruiting	`NCT06418334` - Ultrasonographic Measurement of Diaphragmatic Thickness in Adolescents With Thoracal Hyperkyphosis
Recruiting	`NCT05924581` - Validation of Clinical Assessment of Spinal Stiffness	N/A
Not yet recruiting	`NCT05912478` - Video-Based Game Therapy in Thoracic Hyperkyphosis	N/A
Completed	`NCT04114331` - Feasibility of a Physical Therapy Intervention on Older Adults With Hyperkyphosis or Forward Head Posture	N/A
Recruiting	`NCT05281757` - Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Complex
Completed	`NCT04523597` - "Evaluation of Static and Dynamic Postural Balance in Children With Thoracic Hyperkyphosis"
Completed	`NCT03212664` - Physical Therapy Exercises in Hyperkyphosis	N/A
Terminated	`NCT04008459` - Walking and Balance Related to Sagittal Spinal Posture Alignment
Recruiting	`NCT05763901` - IMU-based Assessment of Motor Control in a Population of Young Subjects With Paramorphisms and Dysmorphisms	N/A