Clinical Trials Logo
  1. Home
  2. Hyperinsulinism
  3. NCT00004825

Short Term Study of Recombinant Human Insulin-like Growth Factor I in Children With Hyperinsulinism

Hyperinsulinism Clinical Trial

Clinical Trial Summary

OBJECTIVES: I. Confirm the inhibitory effect of recombinant human insulin-like growth factor I (IGF-I) on insulin secretion in children with hyperinsulinism.

II. Define the effects of short term IGF-I therapy on postprandial blood sugar levels in this patient population.

III. Characterize the effects of short term IGF-I therapy on fasting behavior, and other insulin dependent parameters, in this patient population.

Clinical Trial Description

PROTOCOL OUTLINE: Octreotide and/or diazoxide are discontinued on day 1, and fasting blood glucose is monitored. Patients receive test meals of Sustacal on days 3 and 4 and are assessed for insulin response.

Beginning on day 5, patients are given recombinant human insulin-like growth factor I subcutaneously every 12 hours for a total of 3 doses. The first dose (on day 5) is given 30 minutes before a Sustacal challenge, the second dose is followed by a bedtime snack, and the third dose (on day 6) is followed by a supervised fast. ;

Study Design

Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00004825
Study type Interventional
Source FDA Office of Orphan Products Development
Contact
Status Completed
Phase N/A
Start date May 1998
Completion date May 1998
View Details
See also
  Status Clinical Trial Phase
Completed NCT00073775 - Epidemiology of Stress and the Metabolic Syndrome N/A
Completed NCT00074451 - Genomewide Search for Loci Underlying Metabolic Syndrome
Completed NCT00005709 - Lipoprotein Metabolism in Hypertensive African-Americans N/A
Completed NCT00005380 - Insulin, Androgen, and Risk in African-American Women N/A
Recruiting NCT05088798 - Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism Phase 2
Not yet recruiting NCT05950282 - Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Completed NCT02248272 - Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes N/A
Completed NCT00937079 - Whole Body 111In-exendin-4 Imaging Study in Insulinoma Patients Phase 1
Completed NCT00151684 - Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men Phase 2
Completed NCT00005530 - Diet, Insulin Resistance, and Cardiovascular Risk N/A
Recruiting NCT05662189 - Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus N/A
Recruiting NCT04744896 - Effects Of Combined Cryolipolysis And High Intensity Interval Training On Insulin Resistance And Body Composition In Polycystic Ovarian Patients N/A
Completed NCT05329337 - Link Between the Peripheral Mononuclear Cells' Capacity to Induce Insulin Resistance and Hyperinsulinemia N/A
Not yet recruiting NCT05989347 - Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy Phase 1
Recruiting NCT05543083 - Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes N/A
Recruiting NCT05774613 - Effect of Hibiscus Sabdariffa Beverage N/A
Recruiting NCT06363929 - Continuous Glucose Monitoring in Neonatal Hyperinsulinism
Completed NCT03358745 - Impact of Meal Order on Postprandial Cardiometabolic Risk Markers N/A
Not yet recruiting NCT05764200 - Acute Microbial Switch N/A
Completed NCT00005654 - Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome N/A