Clinical Trials Logo

Clinical Trial Summary

OBJECTIVES:

I. Determine the dose of recombinant human insulin-like growth factor I that minimizes or decreases the need for exogenous glucose support without causing hypoglycemia.


Clinical Trial Description

PROTOCOL OUTLINE: This is a dose escalation study. Patients receive an escalating dose of recombinant human insulin-like growth factor I (IGF-I). IGF-I is given subcutaneously twice a day. The dose of IGF-I is increased each day for 4 days. Glucose is administered intravenously, when necessary, to prevent hypoglycemia.

Following the study treatment patients resume prior medication and may undergo surgery.

Completion date provided represents the completion date of the grant per OOPD records ;


Study Design

Endpoint Classification: Efficacy Study, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00004699
Study type Interventional
Source FDA Office of Orphan Products Development
Contact
Status Completed
Phase N/A
Start date August 1995
Completion date January 1999

See also
  Status Clinical Trial Phase
Completed NCT00073775 - Epidemiology of Stress and the Metabolic Syndrome N/A
Completed NCT00074451 - Genomewide Search for Loci Underlying Metabolic Syndrome
Completed NCT00005380 - Insulin, Androgen, and Risk in African-American Women N/A
Completed NCT00005709 - Lipoprotein Metabolism in Hypertensive African-Americans N/A
Recruiting NCT05088798 - Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism Phase 2
Not yet recruiting NCT05950282 - Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Completed NCT02248272 - Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes N/A
Completed NCT00937079 - Whole Body 111In-exendin-4 Imaging Study in Insulinoma Patients Phase 1
Completed NCT00151684 - Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men Phase 2
Completed NCT00004825 - Short Term Study of Recombinant Human Insulin-like Growth Factor I in Children With Hyperinsulinism N/A
Completed NCT00005530 - Diet, Insulin Resistance, and Cardiovascular Risk N/A
Recruiting NCT05662189 - Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus N/A
Recruiting NCT04744896 - Effects Of Combined Cryolipolysis And High Intensity Interval Training On Insulin Resistance And Body Composition In Polycystic Ovarian Patients N/A
Completed NCT05329337 - Link Between the Peripheral Mononuclear Cells' Capacity to Induce Insulin Resistance and Hyperinsulinemia N/A
Not yet recruiting NCT05989347 - Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy Phase 1
Recruiting NCT05543083 - Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes N/A
Recruiting NCT05774613 - Effect of Hibiscus Sabdariffa Beverage N/A
Recruiting NCT06363929 - Continuous Glucose Monitoring in Neonatal Hyperinsulinism
Completed NCT03358745 - Impact of Meal Order on Postprandial Cardiometabolic Risk Markers N/A
Not yet recruiting NCT05764200 - Acute Microbial Switch N/A