Control of Hyperglycemia After Cardiac Surgery: CHyCS Trial — CHyCS  

Hyperglycemia Clinical Trial

Official title: Control of Hyperglycemia After Cardiac Surgery: CHyCS Trial

Status Terminated

Clinical Trial Summary

The investigators aim to study the impact of a strategy of a intensive glycemic control in patients undergoing cardiac surgery.

Clinical Trial Description

Patients undergoing heart surgery at the Heart Institute (InCor) will be randomized and in accordance with a list of random numbers, generated by a computer program, are allocated in one of the treatment groups (conventional or intensive) when the blood glucose value recorded is greater than 200 mg/dl on two consecutive measures in an interval of 30 minutes.Conventional Group (GCon): patients randomized to the conventional group will receive insulin infusion in a dilution of 100 units of regular insulin in 100 ml of physiological solution (NaCl 0.9%) in continuous infusion pump for maintenance of blood glucose between 140 mg/dl and 180 mg/dl.

Group intensive (GInt): patients randomized to the intensive group will receive insulin infusion in a dilution of 100 units of regular insulin in 100 ml of physiological solution (NaCl 0.9%) in continuous infusion pump for maintenance of blood glucose between 90 mg/dl and 110 mg/dl.

The insulin dose adjustment will be based on measurements of arterial blood glucose undiluted, held at intervals of one to 4 hours with the use of a monitoring system of glucose and beta-blood ketone (Freestyle Precision Pro, Abbott). The dosage is adjusted according to an algorithm by a team of intensive care nurses, trained for this purpose and assisted by a study physician not involved in the clinical care of patients.

On admission, all patients will receive intravenous glucose solution continuously (200 to 300 g in 24 hours). As soon as possible, the patient will be nurtured according to the routine of Surgical ICU for nutrition in the postoperative period of cardiac surgery patient. ;

Related Conditions & MeSH terms

• Hyperglycemia

• NCT number: NCT02574156
• Study type: Interventional
• Source: University of Sao Paulo
• Status: Terminated
• Phase: Phase 3
• Start date: January 1, 2017
• Completion date: April 1, 2019