Hyperglycemia Clinical Trial
Official title:
Observational Study on the Prognostic Relevance of Admission Glycated Hemoglobin (HbA1C) in Patients With Aneurysmal Subarachnoid Hemorrhage
In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c, clinical course and neurological outcome after 6 month are recorded, to determine whether elevated blood glucose levels prior to aneurysm rupture influence the clinical course and patient outcome after aSAH.
In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is
considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to
estimate the average plasma glucose concentration over prolonged periods of time, thus
determination of glycated hemoglobin at admission after aSAH serves as an approximation of
blood glucose levels in the weeks preceding aneurysm rupture.
In this patient registry admission HbA1c within 72 hours after confirmed aneurysmal
subarachnoid hemorrhage in patients aged over 18 years is determined and correlated with
clinical course and neurological outcome after 6 month as determined by modified Rankin
score. Additionally, patients are monitored for incidence of delayed cerebral ischemia (DCI)
and the incidence of new infarction on the discharge ct scan attributable to DCI. General
treatment of cerebral aneurysm and subarachnoid hemorrhage in all patients follows
international guidelines.
;
Observational Model: Case-Only, Time Perspective: Prospective
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