Effects of Berries on Post-meal Blood Sugar

Hyperglycemia Clinical Trial

— SOMA  

Official title:

Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01580150
• Other study ID #: 247032
• Secondary ID: 70035/09, 1087/3
• Status: Completed
• Phase: N/A
• First received: April 16, 2012
• Last updated: April 16, 2012
• Start date: November 2009
• Est. completion date: January 2012

Study information

• Verified date: April 2012
• Source: University of Eastern Finland
• Contact: n/a
• Is FDA regulated: No
• Health authority: Finland: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

Description:

Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

• Studies 1-2: white wheat bread (starch) is consumed with several berry species

• Study 3: white wheat bread or rye bread is consumed with a mixture of berries

• Study 4: sugar (sucrose) is consumed with berries and berry nectars

• Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: January 2012
• Est. primary completion date: January 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 25 Years to 69 Years

Eligibility

Inclusion Criteria:

• BMI 20-28 kg/m2

• normal fasting plasma glucose

Exclusion Criteria:

• Smoking

• Diabetes or other chronic disease

• Antibiotic medication within the past 3 months

• Blood donation within the past month

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Blood Glucose, Postprandial
• Blood Insulin, Postprandial
• Hyperglycemia

Intervention

Other:
• Berries
Meals containing starch (bread) or sucrose are consumed with berries (150 g) or berry nectars (300 mL).
• No berries
Meals containing starch (bread) or sucrose are consumed without berries.

Locations

Country	Name	City	State
Finland	University of Eastern Finland	Kuopio

Sponsors (1)

Lead Sponsor	Collaborator
Marjukka Kolehmainen

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Plasma glucose		0, 15, 30, 45, 60, 90, 120 minutes post-meal	No
Primary	Plasma insulin		0, 15, 30, 45, 60, 90, 120 minutes post-meal	No
Secondary	Plasma free fatty acids		0, 15, 30, 45, 60, 90, 120 minutes post-meal	No