Hypercholesterolemia Clinical Trial
Official title:
A Study Comparing the Effects of Pitavastatin, Atorvastatin, and Rosuvastatin on Plasma Levels of CoQ10 (SPARQ)
The purpose of this study is to determine if Pitavastatin lowers CoQ10 less than Atorvastatin or Rosuvastatin.
Statins are known effectively treat high cholesterol and heart disease. However, statins may
lower endogenous levels of Coenzyme10 (CoQ10). This decrease in CoQ10 levels may be
responsible for side effects such as myalgia.
Previous studies have shown that Pitavastatin may not affect CoQ10 levels as other statins
do, while still lowering cholesterol.
In this study, investigators intend to compare the plasma levels of CoQ10 in patients taking
3 different FDA-approved statins, in equipotent doses.
;
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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