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NCT00546182 Clinical Trial

Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity

Hypercholesterolemia Clinical Trial

Official title:
Phase 4 Study of Simvastatin That Affects Insulin Sensitivity

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00546182
Other study ID # GMC-200405
Secondary ID
Status Completed
Phase N/A
First received October 17, 2007
Last updated October 17, 2007
Start date January 2004

Study information
Verified date October 2007
Source Gachon University Gil Medical Center
Contact n/a
Is FDA regulated No
Health authority Institutional Review Board: Republic of Korea
Study type Observational

Clinical Trial Summary

We hypothesized simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 25 Years to 75 Years
Eligibility Inclusion Criteria:

- Low-density lipoprotein cholesterol levels more than 100 and body mass index more than 23.0

Exclusion Criteria:

- Patients with overt liver disease

- Chronic renal failure

- Hypothyroidism, myopathy

- Uncontrolled diabetes

- Severe hypertension, stroke

- Acute coronary events

- Coronary revascularization within the preceding 3 months, or

- Alcohol abuse.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Korea, Republic of Gil Medical Center, Gachon University Incheon

Sponsors (1)
Lead Sponsor Collaborator
Gachon University Gil Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (1)

Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):120 — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients
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