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Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light

Hypercapnia Clinical Trial

Official title:
Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light in Elderly Patients Undergoing Laparoscopic Surgery:A Prospective, Randomized Controlled Study

Clinical Trial Summary

The aim of this study is to conduct a prospective, single-center randomized controlled study to investigate the changes of plasma NFL concentration in patients undergoing laparoscopic surgery with mild hypercapnia, and further explore its impact on the central nervous system.

Clinical Trial Description

Plasma NFL concentrations were measured preoperatively and 1 day postoperatively. Secondary endpoints:CAM (Confusion Assessment Method) is conducted to check the subjects' baseline cognitive function preoperative day and 1 day postoperatively to assess whether delirium occurs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05793437
Study type Interventional
Source Affiliated Hospital of Jiaxing University
Contact
Status Completed
Phase N/A
Start date April 1, 2023
Completion date January 28, 2024
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