Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of the Aldosterone / Renin Ratio for the Diagnosis of Primary Hyperaldosteronism — DAPS  

Hyperaldosteronism; Primary Clinical Trial

Official title: Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of the Aldosterone / Renin Ratio for the Diagnosis of Primary Hyperaldosteronism

Status Recruiting

Clinical Trial Summary

collaborative work within 2 hospitals at the CHU of Caen, at the CHRU of Lille, concerning the evaluation of the biological markers of primary hyperaldosteronism (PAH) with the dosage of aldosterone in LC -MS/MS, which is performed in both centers, with two different techniques. The main objective is to define the range of Aldosterone concentrations in LC MS/MS, of renin in an automated method, in populations of healthy volunteers, essential hypertensives, and hypertensives with primary hyperaldosteronism. , in order to establish a threshold for the screening of PAH by the RAR, and for the confirmation of PAH by a dynamic test with an Aldosterone threshold post salt load test.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Hyperaldosteronism
• Hyperaldosteronism; Primary

• NCT number: NCT05640128
• Study type: Interventional
• Source: University Hospital, Caen
• Status: Recruiting
• Phase: N/A
• Start date: January 2, 2018
• Completion date: January 2024