Hydrocephalus Clinical Trial
Official title:
Phenotypes, Biomarkers and Pathophysiology in INPH
The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus (iNPH ) and related disorders in a prospective single center study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the etiology and molecular mechanisms of these diseases.
Due to the heterogeneity of the etiology of idiopathic normal pressure hydrocephalus , almost all published studies on the clinical outcome and prognostic factors of iNPH are relatively limited, and most of them are retrospective. It is not clear which is the most reliable predictor of clinical outcome. Therefore, the researchers conducted this prospective cohort study to identify the occurrence, development and outcome of iNPH and determine the main prognostic factors through clinical scales, biomarkers and imaging. At study visits a standardized clinical examination will be performed including application of clinical rating scales. At all study visits, patients will be asked to donate biosamples; biomaterial collection is optional and participants can elect to participate in sampling of blood, urine, CSF, and/or a muscle biopsy. Optionally, additional examinations may be performed including imaging,such as DTIALPS, neurophysiological examination, analysis of patient or observer reported outcomes and analysis to characterize molecular biomarkers. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06040697 -
Formative Usability Assessment of Wireless Thermal Anisotropy Devices
|
||
Terminated |
NCT02408757 -
Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages
|
||
Terminated |
NCT01863381 -
Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement
|
N/A | |
Completed |
NCT00652470 -
A Study Comparing Two Treatments for Infants With Hydrocephalus
|
Phase 2 | |
Completed |
NCT00196196 -
A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.
|
Phase 3 | |
Terminated |
NCT05501002 -
Pilot Study to Evaluate the CereVasc® eShunt® System in the Treatment of Communicating Hydrocephalus
|
N/A | |
Active, not recruiting |
NCT05068128 -
Combined Flow and Pressure Study of Craniospinal Dynamic
|
||
Completed |
NCT04496414 -
Bactiseal Catheter Safety Registry in China
|
||
Terminated |
NCT02900222 -
Study of Choroid Plexus Cauterization in Patients With Hydrocephalus
|
N/A | |
Recruiting |
NCT04099823 -
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
|
N/A | |
Unknown status |
NCT02775136 -
An Evaluation of a Non-invasive Brain Monitor
|
N/A | |
Completed |
NCT00692744 -
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
|
N/A | |
Recruiting |
NCT04758611 -
The ETCHES I Study (Endovascular Treatment of Communicating Hydrocephalus With an Endovascular Shunt)
|
N/A | |
Completed |
NCT03595033 -
Hydrocephalus iPad-App Based Intervention Study
|
N/A | |
Completed |
NCT04207229 -
CERTAS Programmable Valve Registry
|
||
Terminated |
NCT01973764 -
Intraventricular Drain Insertion: Comparison of Ultrasound-guided and Landmark-based Puncture of the Ventricular System
|
N/A | |
Completed |
NCT01976559 -
Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol
|
N/A | |
Completed |
NCT02381977 -
Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment
|
N/A | |
Recruiting |
NCT06086561 -
Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device
|
N/A | |
Recruiting |
NCT05910944 -
European Study of Prodromal iNPH
|