Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning

Status Not yet recruiting

Clinical Trial Summary

The aim of this study is to analyze our experience in management of malfunctioning ventriculoperitoneal shunt by using endoscopic third ventriculostomy (ETV).

Clinical Trial Description

Cerebrospinal fluid shunting remains the most common line of treatment for hydrocephalus. Endoscopic third ventriculostomy (ETV) is an alternative to cerebrospinal fluid (CSF) shunting that is potentially favorable due to the lack of implanted hardware. Most previous studies of ETV have focused on its role as an initial treatment for hydrocephalus and on comparing ETV with CSF shunting. However ,some patients who have previously been treated with a CSF shunt then developed malfunction are candidate for ETV. The ETV Success Score (ETVSS) is the most widely used scale to estimate the likelihood of ETV success for a given patient . Although the age of the patient is the most important component of the ETVSS, history of previous treatment with a shunt is also included in the model. According to the ETVSS, previous shunting reduces the likelihood of ETV success by approximately 10%. There have been numerous previous studies of ETV in patients with a history of a CSF shunt (post shunt ETV), reporting success rates from 50% to 80% . Two review articles also covered this topic, one of which reported ETV success by meta-analysis in 68% of 519 pooled patients . Most patients with shunt malfunction and or infection are treated with revision procedures, but ETV can be used as an alternative treatment in such cases .The role of endoscopic management of hydrocephalus in shunt malfunction was not investigated extensively so far. There are several studies which have considered ETV as the main treatment of hydrocephalus inpatients with shunt failure. Therefore, this is an attractive topic in neurosurgery especially in pediatric neurosurgery that can work and make a different kind of studies to explore the role of ETV for shunt failure. The goal of the current study was to present our experience with endoscopic third ventriculostomy for management of shunt malfunction. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06341946
Study type	Interventional
Source	Sohag University
Contact	Omar Mahmoud Abellah, M.B.B. Ch, M.Sc
Phone	01114514558
Email	omr.hassan@med.sohag.edu.eg
Status	Not yet recruiting
Phase	N/A
Start date	April 5, 2024
Completion date	November 2025

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning Ventriculoperitoneal Shunt

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms