Huntington's Disease Clinical Trial
Official title:
A Randomized, Double-blind, Placebo-controlled Prospective Crossover Trial Investigating the Efficacy and Safety of the Treatment With Bupropion in Patients With Apathy in Huntington's Disease
The influence of bupropion compared to placebo on the change of apathy as quantified by the apathy evaluation scale (AES-I, where I [informant] is a friend or family member familiar with the daily activities of the subject) in patients with HD after ten (10) weeks of treatment.
The safety and tolerability of Bupropion in HD.
The influence of Bupropion compared to placebo on the:
- change of apathy as quantified by the AES-C (clinician) or the AES-S (self),
- change of motor symptoms (UHDRS) and quantitative grip force motor assessment,
- change of cognitive symptoms (UHDRS and MMSE),
- change of psychiatric symptoms (UHDRS, HADS),
- change of activities of daily living (UHDRS),
- change of the NPI caregivers' distress score (NPI-D),
- change of ventral striatal and ventromedial prefrontal activation in response to a
reward paradigm as quantified by fMRI.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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