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Clinical Trial Summary

SHIELD HD is an international, multisite, prospective, longitudinal cohort natural history study to assess the natural history of HD and its biomarkers that are associated with modulation of the number of cytosine-adenine-guanine (CAG) repeats in the mutant Huntingtin (HTT) gene. Approximately 60 patients will be enrolled into the study and followed for up to 24 months at clinical sites in North America and Europe. The results of this study will inform assessments for a future interventional treatment trial.


Clinical Trial Description

The rationale for this study is to obtain longitudinal information related to Somatic Instability and DNA damage response genes in HDGECs at various stages of the disease. Established assessments of disease progression will also be recorded. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04406636
Study type Observational
Source CHDI Foundation, Inc.
Contact
Status Active, not recruiting
Phase
Start date May 19, 2020
Completion date April 2023

See also
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