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Effect of Pancreatic Polypeptide on Gastric Motor Function and Food Intake in Humans

Hunger Clinical Trial

Official title:
Effect of Pancreatic Polypeptide on Intragastric Pressure and Satiety During Nutrient Drink Infusion

Clinical Trial Summary

The investigators want to observe whether different doses of pancreatic polypeptide infusions influence gastric accommodation (measured as intragastric pressure changes during a liquid meal infusion), gastric emptying and food intake.

Clinical Trial Description

As pancreatic polypeptide (PP) influences food behavior in humans, our research group suggests a role via the the gastric accommodation or gastric emptying. Twelve healthy volunteers participated in this single blind, placebo-controlled, crossover trial. An infusion catheter and a manometry probe were positioned in the stomach. After a 15 min stabilization period, saline (placebo), PP 3 pmol/kg*min or PP 10 pmol/kg*min were intravenously infused. Thirty min after the condition, an intragastric nutrient drink (ND) infusion (60 ml/min) started until the volunteer felt maximal satiated. GE was evaluated using the 13C breath test during the 6 hours following the ND infusion. Satiation and hunger were scored on a visual analog scale every 5 minutes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03854708
Study type Interventional
Source Universitaire Ziekenhuizen Leuven
Contact
Status Completed
Phase Phase 4
Start date August 31, 2010
Completion date March 8, 2011
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