Human Papillomavirus Clinical Trial
Official title:
A Multi-omics Study on the Human Papillomavirus Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
NCT number | NCT03742869 |
Other study ID # | HITA |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | November 10, 2018 |
Est. completion date | November 23, 2021 |
This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | November 23, 2021 |
Est. primary completion date | November 23, 2021 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Confirmed primary adenocarcinoma of the uterine cervix - Signed an approved informed consents - Feasible for biopsy Exclusion Criteria: - Not meeting all of the inclusion criteria |
Country | Name | City | State |
---|---|---|---|
China | Lei Li | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Lei Li |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Frequencies of somatic driving mutations | The differences of frequencies of somatic driving mutations will be compared between patients with and without HPV integration. | Two years | |
Secondary | Frequencies of alteration of RNA expression | The alteration of patterns of RNA expression, including mRNA, miRNA, and lncRNA, will be compared between patients with and without HPV integration. | Two years | |
Secondary | Frequencies of alteration of protein expression and signal pathway | The alteration of patterns of protein expression and signal pathway will be compared between patients with and without HPV integration. | Two years | |
Secondary | Progression-free survival | Progression-free survival between patients with differential expressed multi-omics will be compared. | Five years |
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