Human Papillomavirus Clinical Trial
Official title:
Evaluation of Immune Response Against Human Papillomavirus (HPV)in Patients With Metastatic Cancer of the Anal Canal
Complete response is a rare event in metastatic anal cancer in the case of unresectable
recurrence after radiochemotherapy.
In the University Hospital Center of Besançon, 8 patients with metastatic anal cancer were
treated between 2005 and 2008 by 6 cycles of chemotherapy including taxane: DCF (Docetaxel,
Cisplatin and 5-Fluorouracil.
In more than 90% of cases, anal cancers are related to Human Papilloma Virus (HPV) infection,
that is the case of this patients for which HPV16 (human papillomavirus type 16) genotype was
identified within the tumor samples.
The hypothesis is that an anti-HPV response immune could be generated by chemotherapy with
DCF and contributed to the elimination of the tumour cells and to the increase of complete
responses. The aim to this study is to analyze immune response against HPV in this patients
in complete response.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02740790 -
Immunogenicity and Safety of Human Papillomavirus (HPV)-16/18 Vaccine in Healthy Females
|
Phase 2 | |
| Completed |
NCT01422356 -
Human Papillomavirus (HPV) Infection in Young Men Who Have Sex With Men
|
N/A | |
| Completed |
NCT01159834 -
Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)
|
N/A | |
| Completed |
NCT02808832 -
An HPV Vaccine Provider Intervention in Safety Net Clinics
|
N/A | |
| Completed |
NCT01456715 -
Immunogenicity of Gardasil and Twinrix and the Effect of a Dose of Gardasil or Cervarix Given 42 Months Later.
|
Phase 3 | |
| Completed |
NCT02968420 -
Long Term Immune Memory Responses to HPV Vaccination Following 2 vs 3 Doses of Quad-HPV Vaccine
|
Phase 4 | |
| Completed |
NCT02007421 -
Study of the Prevention of Anal Cancer
|
N/A | |
| Recruiting |
NCT04708470 -
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
|
Phase 1/Phase 2 | |
| Completed |
NCT02267876 -
Longitudinal Clinical Evaluation of the HPV Assay on the BD VIPER LT System With Cervical Specimens
|
||
| Recruiting |
NCT01459289 -
Psychosocial Effect of HPV Positivity
|
N/A | |
| Completed |
NCT01358097 -
Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy
|
N/A | |
| Completed |
NCT01342978 -
Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time
|
N/A | |
| Not yet recruiting |
NCT06434337 -
Evaluation of a Novel Point-of-Care Diagnostic Test for Human Papillomavirus (HPV)
|
||
| Active, not recruiting |
NCT02576561 -
Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL
|
Phase 2 | |
| Terminated |
NCT02503111 -
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
|
N/A | |
| Recruiting |
NCT02126189 -
The Princess Alexandra Hospital and the QIMR Berghofer Medical Research Institute Head and Neck Cancer Study
|
N/A | |
| Completed |
NCT01766284 -
Study of the Diagnostic Efficacy of "Real Time" Niris 1300e Optical Coherence Tomography (OCT) Imaging System in the Management of Pre-invasive and Invasive Neoplasia of the Uterine Cervix
|
N/A | |
| Completed |
NCT01524003 -
Chinese Cancer Prevention Study(CHICAPS)
|
N/A | |
| Recruiting |
NCT05026138 -
Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)
|
||
| Recruiting |
NCT03742869 -
HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
|