Measurements of Water in Breath and Saliva

Human Energy Expenditure Clinical Trial

Official title: Rapid Measurements of Water Isotopes in Human Breath and Saliva for Doubly Labeled Water Analysis

Status Enrolling by invitation

Clinical Trial Summary

This study proposes to demonstrate the feasibility of measuring 2H:1H and 18O:16O in saliva and breath by comparing the natural abundances of 2H:1H and 18O:16O in saliva and urine of un-dosed humans.

Clinical Trial Description

The scientific premises for this line of research are 1) challenges related to costs, the complexity of sample collection and preparation, and the level of technical skills required for Isotope-ratio mass spectrometry (IRMS) analysis have limited the adoption of the doubly labeled water (DLW) method; and 2) the investigators preliminary data demonstrates that Off-Axis Integrated Cavity Output Spectroscopy (OA-ICOS) provides a valid, more rapid, and less technically challenging approach to isotopic analysis of human samples. ;

Related Conditions & MeSH terms

• Human Energy Expenditure

• NCT number: NCT03233256
• Study type: Interventional
• Source: University of Colorado, Denver
• Status: Enrolling by invitation
• Phase: N/A
• Start date: February 27, 2018
• Completion date: December 2025