Hodgkin's Lymphoma Clinical Trial
Official title:
A Multi-Center, Open-Label Phase II Study of Single-Agent GX15-070MS Administered as a 24-Hour Infusion Every 2 Weeks to Patients With Relapsed or Refractory Hodgkin's Lymphoma
Defects in the apoptotic process can lead to the onset of cancer by allowing cells to grow
unchecked when an oncogenic signal is present. Obatoclax is designed to restore apoptosis
through inhibition of the Bcl-2 family of proteins, thereby reinstating the natural process
of cell death that is often inhibited in cancer cells.
This is a multi-center, open-label, Phase II study of single-agent obatoclax administered in
2-week cycles as a 24-hour infusion every 2 weeks at a fixed dose of 60 mg to patients with
relapsed or refractory Hodgkin's Lymphoma. Infusions may be administered on an out-patient
basis. No investigational or commercial agents or therapies other than those described in
the protocol may be administered with the intent to treat the patient's malignancy.
Supportive care measures including those directed at controlling symptoms resulting from
Hodgkin's Lymphoma (blood products, growth factor, etc.) are allowed.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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