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Clinical Trial Summary

Nivolumab is an anti-PD-1 antibody highly effective in patients with relapsed/refractory classical Hodgkin lymphoma. A PET-adapted regimen of Nivo combined with ICE as first salvage therapy was shown to induce high response rates and favorable progression-free survival as a bridge to autologous stem cell transplantation, allowing to omit salvage chemotherapy in a substantial proportion of r\r cHL patients. This study evaluates the safety and efficacy of PET-adapted treatment of nivolumab at the fixed dose of 40 mg in combination with ifosfamide, carboplatin, and etoposide (NICE-40) in patients with relapsed/refractory Hodgkin Lymphoma.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04981899
Study type Interventional
Source St. Petersburg State Pavlov Medical University
Contact Kirill Lepik, MD,PhD
Phone +78123386265
Email lepikkv@gmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date March 1, 2021
Completion date October 1, 2024

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