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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01451697
Other study ID # DIMA003472HI
Secondary ID
Status Completed
Phase Early Phase 1
First received
Last updated
Start date July 2011
Est. completion date October 2012

Study information

Verified date May 2019
Source Hartford Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding. The primary hypothesis is that compulsive hoarding patients who are treated with cognitive remediation will demonstrate improved cognitive skills at post-treatment compared to patients receiving placebo. This will be especially true of attention; memory and executive function skills may also be improved.


Description:

The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding. Previous research has demonstrated that hoarders have diminished neuropsychological abilities, particularly in the areas of attention, memory, and executive function; and that cognitive remediation improves those functions in populations that are similarly impaired, such as in individuals with schizophrenia. The investigators will thus randomize 20 patients with compulsive hoarding to receive either cognitive remediation or a placebo condition. Before and after treatment, the investigators aim to assess the effects of cognitive remediation on neuropsychological functioning and hoarding severity. The primary specific aim is to examine whether cognitive remediation improves cognitive function in compulsive hoarders. The investigators hypothesize that compulsive hoarding patients who are treated with cognitive remediation will demonstrate improved cognitive skills at post-treatment compared to patients receiving placebo. This will be especially true of attention; memory and executive function skills may also be improved. A secondary, exploratory aim is to examine whether cognitive remediation improves hoarding severity, compared to placebo. The ultimate goal of this research is to determine the feasibility and appropriateness of pursuing larger-scale studies of the promising new approach of combining cognitive remediation with other treatments for compulsive hoarding—particularly cognitive-behavioral therapy (CBT).


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Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Cognitive Remediation
A computerized cognitive remediation program focused on attentional training will be used.
Control (Placebo)
The control condition will involve relaxation training.

Locations

Country Name City State
United States Anxiety Disorders Center, Institute of Living/Hartford Hartford Connecticut

Sponsors (1)

Lead Sponsor Collaborator
Hartford Hospital

Country where clinical trial is conducted

United States, 

References & Publications (55)

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Outcome

Type Measure Description Time frame Safety issue
Primary Continuous Performance Task (computerized version): change from Baseline in Attentional Functioning at 8 Weeks This measure is a computerized assessment of attention, memory, and executive functioning. The investigators will use this measure to assess change in those cognitive domains between Baseline (Week 0) and Endpoint (Week 8). Week 0 (Baseline) and Week 8 (Endpoint)
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