Hoarding Disorder Clinical Trial
Official title:
Enhancing Attention in Adults With Compulsive Hoarding: A Pilot Study
Available data suggest that compulsive hoarders have cognitive deficits, particularly with sustaining attention that might contribute their hoarding symptoms.
Status | Completed |
Enrollment | 4 |
Est. completion date | April 2011 |
Est. primary completion date | April 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Clinically significant compulsive hoarding (Proposed DSM-V criteria) that is principal (i.e. currently most severe and needing of treatment) and has been present for at least one year. - At least moderate attentional difficulties. - Able to provide consent. - Patients can be on or off of serotonin reuptake inhibitors (SRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs) but dose must be stable for 12 weeks prior to study. Exclusion Criteria: - Currently taking any psychotropic medications other than SRIs or SNRIs. - Presence of psychotic symptoms or lifetime history of schizophrenia, bipolar disorder or other psychotic disorder. - Current major depression is permitted if clearly secondary in importance to the hoarding. - Judged clinically to be at risk of suicide (suicidal ideation, severe depression or other factors) - Any cardiovascular abnormality that increases the risk of participation, including significant history of cardiovascular disease or family history of sudden death. - Any medical or neurological disorder that increases the risk of participation or that is a medical contraindication for taking methylphenidate (e.g. glaucoma or Tourette's syndrome). - Current use of any drug that is contraindicated with methylphenidate (e.g. monoamine oxidase inhibitors). - Female patients who are pregnant or nursing. - Current or previous treatment with methylphenidate or CBT for hoarding. - Current ETOH/drug abuse or dependence disorder of dependency in the past 6 months. - Individuals with mild cognitive impairments, dementia, or significant intellectual deficits. |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
United States | Institute of Living | Hartford | Connecticut |
United States | New York State Psychiatric Insitute | New York | New York |
Lead Sponsor | Collaborator |
---|---|
New York State Psychiatric Institute | Hartford Hospital |
United States,
Rodriguez CI, Bender J Jr, Morrison S, Mehendru R, Tolin D, Simpson HB. Does extended release methylphenidate help adults with hoarding disorder?: a case series. J Clin Psychopharmacol. 2013 Jun;33(3):444-7. doi: 10.1097/JCP.0b013e318290115e. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Patients Who Met and Exceeded Response Criteria of Attention Deficit Hyperactivity Disorder Symptom Scale | Patients given Attention Deficit Hyperactivity Disorder Symptom Scale (ADHDSS), a measure of the features of Attention Deficit Hyperactivity Disorder including inattention, hyperactivity, and impulsivity. This scale has shown excellent reliability in prior studies of individuals with HD. For the ADHDSS the minimum units are 0 and Maximum units on the total scale are 54 (adult). The higher the number on the ADHDSS, the more severe the symptoms. Response was defined as at least a 30% reduction on the ADHDSS. | 4 weeks | No |
Secondary | Number of Patients Who Met Response Criteria for the Saving Inventory-Revised. | Patients given Saving Inventory-Revised (SI-R), an evidence-based measure of three features of hoarding: excessive acquisition, difficulty discarding, and clutter. For the SI-R the minimum units are 0 and Maximum units on the total scale are 92. The higher the number on the SI-R, the more severe the symptoms. Response was defined as at least a 25% reduction on the SI-R. | 4 weeks | No |
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