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Bitherapy With the Combination of Raltegravir and Darunavir (BIRDi) — BIRDi  

HIV/AIDS Clinical Trial

Official title:
A Retrospective Cohort Study of the Efficacy and Evolution of Comorbidities With the Combination of Raltegravir and Boosted Darunavir in Suppressed HIV-infected Patients With Intolerance or Toxicity to Nucleoside Analogues

Clinical Trial Summary

Retrospective cohort of virologically suppressed HIV-infected patients who received the combination of Raltegravir plus Darunavir boosted with cobicistat or ritonavir, as dual therapy, because or toxicity or intolerance to nucleoside analogues

Clinical Trial Description

This is a retrospective cohort study including those HIV-infected patients who received the combination of raltegravir plus darunavir boosted with cobicistat or ritonavir as dual therapy, due to the existence of toxicity or intolerance to nucleoside analogues, to evaluate:

- efficacy, measured as percentage of patients free of virological failure after 48 and 96 weeks (ITT-e, snapchot analysis) and improvement in CD4+ count

- tolerance (rate of discontinuation and cause, and frequency of adverse events)

- evolution of different comorbidities (renal, bone, cardiovascular events)

Patients will included if they have received at least 1 dose of the dual therapy ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03348449
Study type Observational
Source Asociacion para el Estudio de las Enfermedades Infecciosas
Contact
Status Completed
Phase
Start date December 15, 2017
Completion date June 29, 2018
View Details
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