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HIV/AIDS clinical trials

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NCT ID: NCT04378439 Recruiting - HIV/AIDS Clinical Trials

Appalachian Partnership to Reduce Disparities (Aim 2)

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

By combining two strategies (i.e., peer navigation and mHealth) into a complete, culturally compatible, bilingual intervention to increase the use of needed HIV, STI, and HCV prevention and care services among racially/ethnically diverse GBMSM and transgender women in rural Appalachia. Study Investigators anticipate that participants in the intervention group, relative to counterparts in the delayed-intervention group, will demonstrate increased HIV, STI, and HCV testing.

NCT ID: NCT04359186 Recruiting - HIV/AIDS Clinical Trials

SCOPE Analytic Treatment Interruption Protocol

SCOPE-ATI
Start date: October 15, 2020
Phase: N/A
Study type: Interventional

The goal of this study is to understand the interaction between HIV and the host at the earliest stages when HIV medications are paused. Volunteers with HIV will interrupt antiretroviral therapy (ART) and then have intensive studies preformed two to three times per week. Most will resume therapy within three weeks, even if the virus does not rebound during this time.

NCT ID: NCT04341779 Recruiting - HIV/AIDS Clinical Trials

Simplifying Treatment and Monitoring for HIV (STREAM HIV)

Start date: February 4, 2021
Phase: N/A
Study type: Interventional

This study seeks to determine the clinical efficacy and cost effectiveness of implementing an integrated model for HIV monitoring using point of care (POC) tenofovir (TFV) adherence testing and POC viral load (VL) monitoring in improving ART adherence, maintaining durable VL suppression, and improving retention in care among HIV-positive individuals initiating first-line tenofovir disoproxil fumarate (TDF)-based ART in South Africa.

NCT ID: NCT04239430 Recruiting - HIV/AIDS Clinical Trials

Propositive (Protecting Positive People From Meningococcal Infection) Follow-up Study

Start date: November 26, 2020
Phase:
Study type: Observational

The need for and timing of booster doses of meningococcal vaccines in People Living with HIV (PLWHIV) is currently unknown. As such it is impossible for clinicians to recommend booster doses or to know if and when these might be necessary.We propose to follow up a group of participants from the Propositive study who received two doses of both MenB (Bexsero) and MenACWY (Menveo). This was a group of PLWHIV between the ages 18-45 years. We propose following up these participants at 18 and 30 months post completion of two doses of vaccine and investigating their immunological response.

NCT ID: NCT04212884 Recruiting - Frailty Clinical Trials

Functional Decline and QoL in People Aging With HIV in Asia

Start date: May 1, 2020
Phase:
Study type: Observational

This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people living with HIV (PLWH) in Asia.

NCT ID: NCT04201288 Recruiting - HIV/AIDS Clinical Trials

Brief Acceptance-Based Retention Intervention for Newly Diagnosed HIV Patients

Start date: December 21, 2020
Phase: N/A
Study type: Interventional

The overall aim of this program of research is to test a newly developed intervention, Acceptance-Based Behavior Therapy (ABBT), to improve HIV patients' commitment to medical care. The purpose of the proposed project is to establish the efficacy of ABBT and examine its mechanisms of action. To achieve the specific aims, the investigators will conduct a randomized clinical trial (n = 270), with two treatment arms: ABBT vs. an attention-matched HIV education control condition.

NCT ID: NCT04176172 Recruiting - HIV/AIDS Clinical Trials

Optimizing Tobacco Use Treatment for PLWHA

HTO
Start date: February 17, 2020
Phase: Phase 3
Study type: Interventional

The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and cardiovascular disease, such as tobacco smoking. HIV-infected smokers lose more life-years due to tobacco use than they do to their HIV infection. There have been relatively few studies of tobacco use treatments for PLWHA and systematic reviews show that there are insufficient data to conclude that tobacco dependence interventions that are efficacious in the general population are efficacious for PLWHA. Further, many studies in this area have lacked randomization and a control group, infrequently used an intent-to-treat (ITT) approach and biological verification of tobacco abstinence, and lacked post-treatment follow-up.10 What investigators do know thus far is that behavioral interventions and the nicotine patch yield moderate effects on cessation; and 2 recent placebo-controlled trials - one in France and one by this lab - found that varenicline is safe and effective for treating tobacco use among PLWHA, but yield quit rates that are substantially lower than those reported in the general population. Thus, there is a critical need to rigorously test novel ways to optimize tobacco cessation treatment for smokers with HIV.

NCT ID: NCT04168008 Recruiting - HIV/AIDS Clinical Trials

A Peer-Led Intervention to Improve Postpartum Retention in HIV Care

Start date: March 3, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to test the efficacy of a theory-driven peer intervention for pregnant and postpartum women living HIV. The peer intervention is designed to increase self-efficacy, social support, self-regulatory behaviors, and outcome expectancy in order to improve retention in care and viral suppression postpartum. The intervention will consist of face-to-face prenatal educational sessions, starting in early third trimester, and postpartum sessions scheduled up to three months postpartum.

NCT ID: NCT04166851 Recruiting - HIV/AIDS Clinical Trials

Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men

Start date: November 15, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to examine the utility of neuroimaging technique to evaluate pre-exposure prophylaxis (PrEP) promotion messages for men who have sex with men (MSM) at risk of HIV in Baltimore.

NCT ID: NCT04153136 Recruiting - HIV/AIDS Clinical Trials

Effects of Sacubitril/Valsartan on Subclinical Heart Failure in HIV (The ENCHANTMENT HIV Study)

Start date: September 11, 2020
Phase: Phase 2
Study type: Interventional

Persons with HIV, even those well-treated, are at increased risk for heart disease when compared to the general population. Two hormones called aldosterone and brain natriuretic peptide (BNP), which have been shown to be abnormal in HIV, may be associated with inflammation as well as early changes in structure and function of the heart. This study is being conducted to evaluate whether therapies to block aldosterone and increase BNP levels may reduce the burden and progression of heart failure to improve cardiovascular health.